Search results for "Deleterious mutation"

showing 3 items of 3 documents

EFFECT OF DELETERIOUS MUTATION-ACCUMULATION ON THE FITNESS OF RNA BACTERIOPHAGE MS2

2000

RNA viruses show the highest mutation rate in nature. It has been extensively demonstrated that, in the absence of purifying selection, RNA viruses accumulate deleterious mutations at a high rate. However, the parameters describing this accumulation are, in general, poorly understood. The present study reports evidences for fitness declines by the accumulation of deleterious mutations in the bacteriophage MS2. We estimated the rate of fitness decline to be as high as 16% per bottleneck transfer. In addition, our results agree with an additive model of fitness effects.

GeneticsExperimental evolutionMutation rateBase SequenceGenotypeRNABiologybiology.organism_classificationNegative selectionMutationBacteriophage MS2GeneticsFitness effectsGeneral Agricultural and Biological SciencesDeleterious mutationEcology Evolution Behavior and SystematicsDNA PrimersLevivirusEvolution
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Genomic determinants of protein folding thermodynamics in prokaryotic organisms.

2004

Here we investigate how thermodynamic properties of orthologous proteins are influenced by the genomic environment in which they evolve. We performed a comparative computational study of 21 protein families in 73 prokaryotic species and obtained the following main results. (i) Protein stability with respect to the unfolded state and with respect to misfolding are anticorrelated. There appears to be a trade-off between these two properties, which cannot be optimized simultaneously. (ii) Folding thermodynamic parameters are strongly correlated with two genomic features, genome size and G+C composition. In particular, the normalized energy gap, an indicator of folding efficiency in statistical…

Models MolecularProtein DenaturationProtein FoldingProtein familyArchaeal ProteinsThermodynamicsdeleterious mutationsthermophilic proteinsBiologymonte-carlo algorithmGenomeNegative selectionBacterial ProteinsStructural BiologyMolecular evolutionGenome ArchaealevolutionbuchneraMolecular BiologyGenome sizeGeneticsPrincipal Component Analysisacid side-chainsBacteriaSequence Homology Amino Acidreplica approachComputational BiologystabilityGenetic codeArchaeaPRI BioscienceFolding (chemistry)endosymbiotic bacteriacation-pi interactionsThermodynamicsProtein foldingHydrophobic and Hydrophilic InteractionsGenome BacterialJournal of molecular biology
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Nonlinearities in plant RNA virus fitness

2012

Una de las mayores amenazas tanto para la salud humana y animal, como para la agronomía es la emergencia de nuevas enfermedades infecciosas, la mayoría de las cuales están causadas por los virus de RNA. La emergencia viral es un problema complejo que consista en la adquisición de la variación genética, por mutación o recombinación, dentro de la población viral en el huésped reservorio la cual podría facilitar la capacidad de infectar de manera eficiente nuevos huéspedes. Los virus de RNA presentan a una evolucionabilidad extraordinaria por sus grandes tamaños poblacionales, cortos tiempos de generación y altas tasas de mutación y recombinación. Comprender los mecanismos evolutivos que podrí…

virus evolutionepistasisgenome architecturegenotype-by-environmentUNESCO::CIENCIAS DE LA VIDA::Otras especialidades de la biologíafitness landscapesEmerging viruses; RNA viruses; Tobacco etch virus; Viral fitness; Generalism vs. specialism; Genotype-by-environment (G×E) interactions; Epistasis; Adaptive fitness landscapesdeleterious mutations:CIENCIAS DE LA VIDA::Virología [UNESCO]UNESCO::CIENCIAS DE LA VIDA::Genética ::Genética de poblacionesemerging viruses:CIENCIAS DE LA VIDA::Genética ::Genética de poblaciones [UNESCO]UNESCO::CIENCIAS DE LA VIDA::Virología:CIENCIAS DE LA VIDA::Otras especialidades de la biología [UNESCO]
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